Based on the available information, the GermGuardian Airsafe+ appears to be quite effective at reducing allergens:

1. HEPA filtration: The air purifier uses a True HEPA filter that captures 99.97% of particles as small as 0.1 microns[6]. This includes common allergens like dust, pollen, pet dander, and mold spores.

2. Multi-stage filtration: It employs a multi-stage filtration system, including:
– A pre-filter to trap larger particles like dust and pet hair
– An activated carbon filter to reduce odors
– The True HEPA filter for fine particle removal[2]

3. 360-degree air intake: The 360-degree design allows the air purifier to draw in air from all directions, providing more effective and efficient air filtration[2].

4. Coverage area: It can circulate and filter air in a 226 sq. ft. room every 12.5 minutes or every 60 minutes in a 1000+ sq. ft. room[6]. This indicates good coverage for various room sizes.

5. Intelligent operation: The Intellisense Air Quality Indicator measures air quality 60 times per minute and adjusts fan speed as needed, ensuring optimal allergen removal[6].

6. Additional UV-C technology: While not directly related to allergen removal, the UV-C light can help reduce airborne germs, bacteria, and mold spores, which may contribute to overall air quality[6].

7. User reviews: Many users report significant improvements in allergy symptoms after using GermGuardian air purifiers[3].

While specific performance data for the Airsafe+ model is not provided, GermGuardian air purifiers generally perform well in reducing allergens. For example, in tests of a similar model (AC4825E), it cleared 63% of 0.3 micron particles in 15 minutes on the highest setting after matches were burned[3].

Overall, the GermGuardian Airsafe+ appears to be an effective option for reducing allergens in indoor environments, particularly for those with allergies or asthma.

Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9735963/
[2] https://www.amazon.com/Guardian-Purifier-Pollutants-Verified-AC4625BDLX/dp/B0BXQFXDX5
[3] https://www.livescience.com/germguardian-ac4825e-review
[4] https://www.bestbuy.com/site/germguardian-15-inch-air-purifier-with-360-degree-true-hepa-pure-filter-and-uv-c-light-for-150-sq-ft-rooms-white/6425330.p?skuId=6425330
[5] https://www.goodhousekeeping.com/appliances/air-purifier-reviews/g22866172/best-air-purifiers/
[6] https://www.costco.com/germguardian-airsafe+-intelligent-air-purifier-with-hepa-filter,-uv-c,-air-quality-monitor.product.4000309631.html